Hi,
For LPC1768, the P2[10] pin is multiplexed P2[10]/EINT0/NMI, furthermore, it is an ISP pin, in other words, if you connect external pull-down resistor to the pin, after you download application code to the flash of LPC1768, after Reset, the LPC1768 will enter ISP mode, it can not execute application code. But I think the pull-down resistor on the P2[10] does not take effect on programming LPC1768 with JTAG.
In general, user has to connect the P2[10] pin to a hardware button, when user wants to enter ISP mode to download application via uart, he can press the button so that the P2[10] is low, the LPC1768 enters ISP mode after Reset. When user wants to execute application code, just keep the button in release state, the P2[10] will be high, application code will be executed after Reset.
Hope it can help you
BR
XiangJun Rong