MK22FN128VLH10:
100 MHz ARM Cortex-M4 core with DSP instructions delivering 1.25 Dhrystone MIPS per MHz
USB full-speed device crystal-less operation, it has internal 48MHz oscillator.(Cost Effective)
24KB SRAM, larger that 16KB( MK20DN128VLH5 )
Lower Budgetary Price excluding tax
Kinetis SDK supported.(If you have not used KSDK2.0, please read Introducing Kinetis SDK v2 first. You can download and install it refer the methods in How to: install KSDK 2.0.)
But the MK22FN128VLH10 don't have internal USB regulator(It doesn't have VREGIN and VOUT33, only have USBVDD pin), you need refer "3.9.1.2 USB Power Distribution" in K22P121M100SF9RM.
I am not sure: is this can be established with the K20/K22 chip? Maybe you can ask another question.
Robin