Hi,
First of all, sorry for the later reply.
NXP provides AN12239 about how to enable HyperRAM with i.MX RT.
Please check here for the related software demo.
And please check below test performance about i.MXRT1050 works with HyperRAM (S27KS0641@1.8v):
Enabling cache to improve Hyper RAM performance more:
Test 1: Disable Cache (HyperRAM MPU config: non-shareable; Cacheable; Write back; Disable Dcache)

Test 2: Enable Cache (HyperRAM MPU config: non-shareable; Cacheable; Write back; Enable Dcache)

Wish it helps.
best regards,
Mike