Hi @ShashiKumar
Thank you for reaching out.
We would need to analize if this a HW problem. First of all check your design against our RT1010 Harware development guide ( MIMXRT1010HDUG ).
Some couple of things I would check then are:
1 Check connection using our MCUXpresso Secure Provisioning Tool , to this help us to rule out any MCU Boot Utility issue. The connection can be done this way.

2 Given your goal to program and run an application, you can check if it is possible to establish connection with the ROM bootloader but using LPUART1 pins. The pins that the bootrom uses are here.

You mentioned about USB problems so we can discard USB temporally and focus on getting something running on the MCU.
3 If you are able to program over JTAG but not able to execute. There are some points to check:
a) Application image boot headers not being correct for your target flash memory,
b) fuse setup, it is better to do board bring up without any fuse programmed. For example fuses can control boot flow and security aspects, like encryption and secure boot.
c) check if you can run a program linked and programmed only to internal RAM. This to narrow down the issue, in case the program can not execute in external flash memory.
I wish this could help you!
Diego