Hey Luis,
First of all thank you for pointing me to the proper documentation!
Regarding your question, we are going to use 2 layers for our PCB, since the signals that the processor needs to monitor are quite few but very critical. 4 Layers is still an option if really needed.
In the specified stack-up, I see that 0.5oz copper + plating (so around 1oz) is used. Nothing is mentioned for thicker copper layers, but I have checked with PCB suppliers and the minimum clearance for a 2oz copper PCB is around 0.15mm, which seems sufficient.
The LQFP100 or the QFN48 are the packages we are considering for the application, since they are most forgiving in terms of clearance between pads, with QFN having 0.25mm being the most likely candidate.
I will check the documentation thoroughly and proceed with designing.
Thank you very much!
Best Regards, Vasilis