Hi, StanleyH,
As you know that the FlexComm3 module(FC3 module) can be configured as Uart, SPI, I2C and I2S, if the FC3 is configured as I2C, it's signal pads SDA/SCL pins are Open Drain, the external pull-up resistor are required. Of course, if the FC3 is configured as SPI, the SPI signals are push-pull driven, the external pull-up resistors are unnecessary, but the 2.2K ohm pull-up resistor does take effect on the SPI data transfer.
This is the FC3 signal assignment for LPC55S69:
PIO0_2, FC3_TXD_SCL_MISO_WS, the pin is SCL signal of I2C if FC3 is configured as I2C.
PIO0_3, FC3_RXD_SDA_MOSI_DATA, the pin is SDA signal of I2C if FC3 is configured as I2C.
PIO0_4, FC3_CTS_SDA_SSEL0, the pin is SDA signal of I2C if FC3 is configured as I2C.
In conclusion, all the above pads are possible to function as I2C signal, so pull-up resistor are connected in EVK in case they are I2C signals.
Hope it can help you
BR
Xiangjun Rong