Hi,
I suppose that you misunderstood the function of the pins: RST, ISP,uart_TXD and UART_RXD.
First of all, the PIO0_5 pin for LPC55S69 is ISP pin, the RESET_b pin and PIO0_5 pins are not necessary to connect to the FTDI chip, on the LPC55S69 target board, you need to connect the PIO0_5 pin to a button or a jumper so that you can control the PIO0_5 pin high or low after Reset.
The RESET_b pin is required to be connected to a RC circuit and button(the RESET_b pin is low after you press the button).
With PIO0_5 Low during/after Reset, the LPC55S69 enter ISP mode, you can use the FTDI to transfer application code. During the transfer, the PIO0_5 do not need to control, only need to remain low.
With PIO0_5 high during/after Reset, the LPC55S69 executes application code.

This is the uart pin, you have to use uart0 to transfer application code.

You can use blhost.exe on PC side to download code via uart.
Pls refer to UM11126.pdf
Hope it can help you
BR
XiangJun Rong