Hello @ED8500
1) "Since flexcomm2 has a couple of pins to be used as i2c bus, is there any restriction on what pairs of pins used to form the i2c bus together?"
->> No, you can refer to your requirements to choose.
2) "Is there a way to use Flexcomm2 as an i2c bus on the eval LPC55S69-EVK board?"
->> Yes, you can refer to I2C demo under SDK to config:
Alice_Yang_0-1704701233385.png
Recommend you first confirm demo can work well on you side, then change code based on it.
Or you can use MCUXpresso config tool inside MCUXpresso IDE to config pins and also peripheral:
Alice_Yang_7-1704701442572.jpeg
BR
Alice