Hi frank-lin-Sunon
Please make sure you follow the right process before enter power down mode. especially configure FRO as main clock
ZhangJennie_0-1641888156563.png
besides, please also make sure if you well configure I2C as wake up
ZhangJennie_1-1641888237276.png
when checking, use logic analyzer to measure I2C clock and data, if there is correct signal there.
Hope this helps,
Jun Zhang