Hi @Lukas_Frank,
1. Yes, the Host is a PC. I apologize for the confusion.
2. The thing about serial download mode, is that it enables communication to the chip using the Serial Download Protocol (described on section "Serial Download Protocol (SDP) " of the RM and here). Like the post that I previously shared mentioned (link), the flashed code can sometimes cause the debugger to loose access to the RT, rendering it unresponsive and unprogrammable. When this is the case, serial downloader mode is used to regain debug access by allowing the RT to turn on and communicate with a host (PC), without executing any code already stored in flash. This allows the PC to erase the flash and therefore regain control of the RT device.
BR,
Edwin.