No.
On i.MX8M Plus, the RDC semaphore “processor” is a bus master / RDC master, not an individual A53 core. The A53 cluster appears as one A53 platform master/domain for RDC purposes. The A53 quad-core cluster is treated as a single master domain, meaning all four A53 cores (core0–core3) belong to the same RDC domain. As a result, the Sema42 semaphore's GTFSM field identifies which domain (e.g., A53 cluster vs. M7 core) holds the lock, not which individual core within the cluster.
So if A53 core0 locks the semaphore for UART1, A53 core1–3 are not individually blocked by that RDC semaphore. They can still access UART1 if they are in the same A53/RDC domain.
For intra-cluster core isolation, you would need to rely on software-level mechanisms (such as OS-level resource management or spinlocks) rather than the hardware RDC/Sema42.