Hello,
How are you handling the NMI (Non-Maskarable Interrupt )? You can refer to this document as this is also for a cortex M0+.
Please check the chapter 2.1.3.4.1 RESET_b and NMI_b for hardware recommendations, also there are some examples, that also disable it bye SW.
I believe the NMI might be the root cause of your issue; if this does not solve your issue, let me know.
Regards,
Estephania