Thank you for submitting your question, we really appreciate your interest in our products.
The PN5180 IC is able to change its configurations without a RESET but, this isn't shown in any of our examples from the NFC Reader Library. My recommendation is that please explore the possibility of doing this without the library. In the next Application Note, AN12650 will guide you to use the PN5180 without a library.
Please check the Datasheet commands (section), specially LOAD_RF_CONFIG and UPDATE_RF_CONFIG. These commands will manage the configuration changes that will be toggled while the application is running.
Unfortunately, the support for doing this is out of our scope.
I hope this information may have been useful.
Best Regards,
Fabian