Hello!
The issue where LPI2C_Get_MasterTransmitDataRequestEvent(BaseAddr) returns false after 5-10 minutes of continuous I2C reading could stem from I2C bus problems (clock stretching, noise, slave issues), the LPI2C peripheral entering an error state (missed ACK, timeout, FIFO issues), or subtle problems in the software handling of interrupts (flag clearing). Debugging steps include implementing error handling, monitoring bus signals, checking the LPI2C status register, reviewing timeout configurations and slave device documentation, simplifying the test case, introducing delays, and verifying clock/power stability. The key is to identify if the bus is failing, the peripheral is erroring out, or the interrupt flag isn't being correctly managed over the extended read period.