Hi Nanjun,
I can't find the SMRTB-FHG-1250-CS1111 datasheet.
But anyway, you are right, the single ended connection can be between the MCU and the 1st LED chip.
You can refer to the INLC10AQ datasheet.
In chapter 2 Application, there are a few examples.
As you can see, “the capacitive load that correlates with the cable or trace length of the connection between the first device and the μC has to be minimized.”
The datasheet also states: “If it is not possible to locate the μC closely to the first LED, the INLC100Q can also be used as a converter that is placed near to the μC. The device converts the single ended signal to a differential signal which can be transmitted over longer distances.”
Regards,
Daniel