Hi @jerryrig,
Normally, this error means that the GDB has not been found and cannot be launched.
There are two main reasons:
- You are trying to debug as an x86 application. Please make sure to select GDB PEMicro Interface Debugger:

- When creating the project, "C/C++ project" was selected instead of "S32DS Application Project".
If this still does not work, try to specify the path for the GDB executable inside the debug configurations:

You can try "C:\NXP\S32DS.3.4\S32DS\tools\gdb-arm\arm32-eabi\bin\arm-none-eabi-gdb.exe", it was discussed in these community posts: Solved: Segger - Error while launching command: arm-none-eabi-gdb --version - NXP Community & Troubleshooting Tips: Failed Debugging with GDB | MCU on Eclipse.
Also, there is also this MCUonEclipse post for troubleshooting this issue: Troubleshooting Tips: Failed Debugging with GDB | MCU on Eclipse.
Best regards,
Julián