Dear Kawabata-san,
If there is no need to reconfigure and monitor the status of the device during the operation, it is possible to operate it without I2C, there is no periodic watchdog required etc. like in other PMICs.
Having said that, we do not recommend this type of operation, even if there is no need to modify the default settings, having the ability to read the fault statutes etc. is often required and useful.
Best regards,
Tomas