In the data sheet for SC16IS752 (and even SC16IS750) the IRQ Pull-Up Resistor value is recommended 1 kOhm for 3.3 V supply. What is the cause ? What will occur with a pullup as high as 33 kOhm ? There is no value given for the leakage current (for GPIO it's 1 µA, for SPI it's 10 µA).
We design a low power circuit with a quite long interrupt response time and would not spend 3.3 mA over several seconds when the rest of the circuit runs on 2 mA.