Hi @Transidico,
You can calculate the clock cycles required for the operation with the assembly instruction.
MCUXpresso has the option to see the assembly instruction required for each line in C
Pablo_Ramos_0-1744136989528.png
The instruction will appear while debugging.
Pablo_Ramos_2-1744137015557.png
On the core documentation you should be able to find the number of cycles spend on each instruction.
Cortex-M0+ Technical Reference Manual r0p1
However, I suggest you double check directly with ARM to ensure performance on each instruction.
Best Regards,
Pablo