Hello Henning,
This time I use the demo under SDK_2.5.0_LPC54018-IoT-Module with LPC54018 IOTmodule (OM40007).
When debug, yes, the same issue with yours, while after disconnect debugger, reconnect the USB again,
it can recognized the Virtual com Port:

How about on your side?
My PC is Win10 64 bits, what about yours?
Have a great day,
TIC
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