Hi,
Pls refer to the ppt page screenshot.
CFG[REFSEL]=0, the ADC reference voltage is the external pad VREFP voltage.
CFG[REFSEL]=1, the ADC reference voltage is the VREF_OUT voltage, in the case, you have to initialize VREF_OUT module. Pls refer to Chapter 52 Voltage Reference (VREF)
CFG[REFSEL]=2, the ADC reference voltage is the VDDA pin power supply voltage.

Because the UM of LPC553x is not clear, per external customer requirement, I post it here.
BR
XiangJun Rong