Hi,
I suppose that you misunderstood the function of the pins: RST, ISP,uart_TXD and UART_RXD.
First of all, the PIO0_5 pin for LPC55S69 is ISP pin, the RESET_b pin and PIO0_5 pins are not necessary to connect to the FTDI chip, on the LPC55S69 target board, you need to connect the PIO0_5 pin to a button or a jumper so that you can control the PIO0_5 pin high or low after Reset.
The RESET_b pin is required to be connected to a RC circuit and button(the RESET_b pin is low after you press the button).
With PIO0_5 Low during/after Reset, the LPC55S69 enter ISP mode, you can use the FTDI to transfer application code. During the transfer, the PIO0_5 do not need to control, only need to remain low.
With PIO0_5 high during/after Reset, the LPC55S69 executes application code.
xiangjun_rong_0-1736490229442.png
This is the uart pin, you have to use uart0 to transfer application code.
xiangjun_rong_1-1736490868669.png
You can use blhost.exe on PC side to download code via uart.
Pls refer to UM11126.pdf
Hope it can help you
BR
XiangJun Rong