Hi Miguel, thank you for the answer.
However I think there was a misunderstanding. The MCU is not bricked, after a power cycle (and setting high all ISP pins) the application starts correctly.
The problem happens when the internal Boot ROM starts correctly because of some ISP pins sensed low. In this situation, the RESET pin appears not active so it's impossible to restart by pressing the RESET pushbutton. The only way to exit from internal bootloader (Boot ROM) is with a power cycle (cutting off the power supply).
Is it normal? I think the external signal on the RESET pin should be highest priority, even against internal bootloader.