Hi Nicolas Giussani,
From the datasheet of K22, we can get this information:

Your VREFH is 2.5V, so you should make sure your adc input is in range[0, 2.42v] in 16-bit differencetial mode, other mode, the input adc voltage should in the range [0,2.5v], otherwise, your adc input pin maybe damaged.
Wish it helps you!
If you still have question, please let me know!
Have a great day,
Kerry
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