@guoweisun and thanks for support.
I tried what you suggest just for led 0 but nothing is happening. Following the commands I send and the device responses:

One think to consider, looking to the schematic , the LEDS power supply is not Vdd of the PCA9865 chip (3,3V) but its 5V...dont think this is an issue since I configure the GPIO like opendrain .
As you can see I correctly write LED0_ON_L=0x00 and LED0_ON_H=0x10 and i can even read the value back of the LED_ON_H back and just written correctly: im sorry but nothing happens into my board.
Traces on the PCB seems to be ok infact when i give power to the board , all RED led are on (dont know whyhonestly) , but when i send the first command (INVRT=1), they goes all down.
Do you have some ideas? Is the schematic the issue?