Hi,
First of all, sorry for the later reply.
Do you have IMXRT1050-EVKB board on hand? If yes, please check if this EVK board also exist the same behavior?
I also recommend customer to refer < i.MX RT Hardware Development Guide for the MIMXRT1050/MIMXRT1060 Processor > document.
For the USB design, there with below tip for your reference:
USB_OTG1 interface or LPUART1(GPIO_AD_B0_12 and GPIO_AD_B0_13) should be reserved for
NXP flashloader tools, including firmware update, security and Fuse by setting BOOT MODE as serial
download mode. And of course USB_OTG1 can be used as normal USB 2.0 function. Besides, one thing should be taken care that USB TVS protection diode should select corresponding part for full-speed and high-speed USB application.
Wish it helps.
Mike