Hi Ian,
1 Yes. When the RST bit is set, the boot mechanism resets all functional block registers and loads the respective internal registers with their default values. At the end of this boot process, the RST bit is internally hardware cleared.
2. We recommend a 1 ms delay between issuing a software reset and attempting communication with the device over the I2C bus.
Regarding interrupts, going into standby mode does not clear active interrupts.
Best regards,
Tomas