Hi @SaschaH ,
Are you referring to IO1 and IO2? Actually they can also be used as I2C Master interface for the Sensor/Actuator use case as described in AN12449(https://www.nxp.com/docs/en/application-note/AN12449.pdf ), but they can not be used as GPIO.
In case you would like to control a GPIO via the middleware you have to connect the device with an I2C-bus I/O expander and follow the cases mentioned in AN12449.
Hope that makes sense,
Have a great day,
Kan
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