Hi @fengba_360,
I can see you have the "Skip All Breakpoints" option enabled, could you try debugging while this option is disabled?

This issue may be caused by the debugger not being able to enter the first breakpoint at main, since the pre-run/restart option only issues a reset and halt to the MCU after flashing the project:

If this issue keeps happening, you can also try to contact the SEGGER - Forum directly.
Best regards,
Julián