Hello @seanwu ,
You are correct that NTB0102GT is not suitable for I²C communication. The correct part for I²C level shifting should be NTS0102. NTB0102 and NTS0102 share the same footprint, so replacing NTB0102 with NTS0102 is straightforward
On the S32K388EVB-Q289, NTB0102GT is currently populated, which means that using LPI2C1 through this translator may lead to unreliable communication.
NXP provides a FS56 Generic Software Driver with Examples, available on the FS5600 product page:
https://www.nxp.com/products/FS5600

Best regards,
Pavel