Hi @rekhak
I am afraid I am not familiar with Vector DaVinci, so my observations are based on a comparison between the S32DS configurations and the S32K3xx Reference Manual information.
The LPI2C configurations appear generally correct. However, I have one observation regarding the interrupt configuration. Specifically, for the ISR Interrupt Priority parameter, you assigned a value of 144. According to the S32K3xx Reference Manual, there are 16 priority levels, which are configurable using 4 bits in the IRQn fields of the NVIC IPRn registers. Furthermore, based on the NVIC_SetPriority() function, only the upper 4 bits of the 8-bit priority field are implemented, meaning that only values from 0 to 15 are valid.

For clarity and maintainability, it is recommended to use values within the 0–15 range directly.
Additionally, could you please confirm whether the same configuration works correctly for LPI2C0? From what I can see, there does not appear to be an issue with the current configuration, so verifying its behavior on LPI2C0 could help us rule out a direct issue with LPI2C1.
BR, VaneB