Hi @mokhaledbec
Model-Based Design Toolbox for S32K3 (v1.6.0) integrates RTD version 5.0.0, which was developed and tested using S32 Design Studio (S32DS) version 5.0.0. However, based on my experience, it also works without issues in S32DS version 3.6.
For guidance on tool setup and getting started, I recommend referring to the Model-Based Design Toolbox S32K3 Series Quick Start Guide and the Release Notes. These documents are available on the same page where you downloaded the MATLAB .mltbx file.
BR, VaneB