Hi,
the only way i see is to turn off external power supply VSUP.
The VSUP supplies the internal voltage regulator from which the VDDX is derived.
However, there is Voltage Regulator Control Register (CPMUVREGCTL) and there are the EXTXON and INTXON bits which controls what voltage regulator will be used in the application, external or internal. If the EXTXON bit is zero, the INTXON must be one and the VDDX does not use external BJT. It is derived from internal VREG.
Otherwise, if EXTXON=1, then INTXON=0 and internal VREG is selected.
Still, this option may not be much helpful in your case as the CPMUVREGCTL register is WRITE ONCE in Normal mode. So after MCU reset, this register must be written to select the VREG for VDDX domain.
Regards,
iggi