For your schematic:
1:Pin47 need 2.2uF decouple capacitor
2:The input capacitors for LDOX are 1uF
3:Pin 48 connect it to ground.
4:Pin21 pull up to VDDIO with 100K
5:You can try to read below registers for confirm the fault.

I will close your case 00958417 and please neglect its survey request.
At last please let me know the read registers result after update your schematic.