Hello Sandeep,
IO2 and IO3 are logic-level local inputs and are not designed to be connected directly outside the ECU. Their absolute maximum voltage range is only −0.3V to 8V.
If they must be used for an external wake-up source, a separate automotive-qualified, load-dump capable input-conditioning or level-shifting circuit would be required. This circuit must ensure that the voltage at IO2 or IO3 remains within the pin ratings under all normal and transient conditions and that the specified input thresholds are satisfied.
BR, Tomas