Hello,
The Control_1 register (0x00) should have the SI (Second Interrupt) bit set if you want a 1-second interrupt. You wrote:
[I2C address = 0x51, write bit = 0, register = 0x00, data = 0x01]
This sets only the STOP bit to 0, but may not enable the SI bit. You might need to write:
[I2C address = 0x51, write bit = 0, register = 0x00, data = 0x21]
If this does not work, please confirm how Control_1 register is configured.