Hello [email protected],
We are talking about the same mot file? So if you manually program the generated mot file, it runs? Are you sure that the generated code reaches the board automatically? Because from your screenshot, the Download Code after Build is not checked, so the model will generated only the mot file and will not flash the mot on the controller.

Consider checking the the Download Code after Build, select OpenSDA if you are trying to run this code on the EVB or you have an OpenSDA and then select the correct Drive Name.
If my understanding is wrong, consider attaching your model to have a closer look on your settings.
Hope this helps you,
Marius