I can't really speculate what has happened. Are you using a JTAG or SWD connection to the board? I suggest you remove power to the board, then reapply power whilst holding down the ISP button. Release the button, then use the flash dialog to mass erase the flash. Once complete, try flashing a do nothing program, like the LPCOpen blinky program.
LPCOPEN-SOFTWARE-FOR-LPC43XX
I think you'll need to login now to download.
Thanks and regards,
LPCXpresso Support