Hi
There are no issues using USB and UARTS/LPUARTS at the same time.
See the following for references that do this:
- http://www.utasker.com/kinetis/FRDM-KL27Z.html
- http://www.utasker.com/kinetis/Capuccino-KL27.html
The only thing to possibly be aware of is if you use the IRC48M as clock source it will be drifting a little when USB is not connected but become locked to 48M form the host when it is (and USB crystal-less mode is in operation).
This could slighty change the UART speed in the two states but it shouldn't be noticeable in normal cases.
If you prefer an industrial quality out-of-the-box solution for the KL27 (with various proven USB classes: CDC, HID, MSD, Audio, RNDIS and optimised UART/LPUART with DMA support) for KDS, CW, IAR, Keil, Green Hills, Crossworks, CooCox, GCC, or VisualStudio Kinetis simulation you can get it from the links.
Regards
Mark
Kinetis for professionals: http://http://www.utasker.com/kinetis.html