Hi Richard,
From the 24C16 datasheet, we can know that, the device select code is like following:


So, you can configure the device code+memory MSB addresses as the PE I2C target slave address, then write the I2C code, follow the Byte ADDR in the code, this Byte code, you don't need to add in the PE I2C address configurations.
Wish it helps you!
If you still have question, please contact me!
Have a great day,
Jingjing
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