Hello Scott,
How are you? I'd like to know if you are using same DMA's source trigger (in this case, I2S TX trigger) to generate the trigger signal for both DMA channels (TCD)? In this the case you are facing?
If so, then, there is a note in the reference manual that talks about avoid to use the same source trigger for two or more channels (eventhough one channel is disabled) because it can result on an unpredicted behavior:

This note is taken from Channel configuration register (DMAMUX_CHCFGn) in DMAMUX chapter.
That would explain the fact that this error is not presented when DMA is disabled.
As a workaound, you can try to use two linked channels to move data to I2S TX, however, this data will won't be synchronized and channel 2 needs to wait until channel 1 has finished.
I hope this can help you!
Best Regards,
Isaac