I'm working with the K22 and removed power from the chip, however kept I2C0_SDA and I2C0_CLK on PORTB connected to the I2C bus. When I keep them connected while the chip is powered down, it pulls the entire I2C bus down. When I remove the K22 from the bus, the bus operates as it should.
What can I do, from the K22 side, to prevent this from happening, as I believe the pull-down is internal to the chip itself?