Tough question. I thought this one would be easy to find an answer to, but there's nothing in the Data Sheets or Reference Manuals. Searching for "unconnected" and other keywords in this forum doesn't find anything useful either.
I guess I could say you have to obey the Minimum and Maximum Ratings for these voltages in the Data Sheet, and that maybe you can't guarantee to meet these specs if those pins are gloating.
From a practical standpoint, "floating" is always bad. You may also be straying into a region of operation the designers haven't considered or tested.
The best answer for this is "design your board as close to the reference design as possible". That design is well tested, supported and understood. Do anything different at your peril.
Tom