> I want to use UART0 with on TX and RX signal (no control signal needed).
> I can set RX and TX for UART operation a RTS and CTS as GPIO pins?
Yes, you can use TXD and RXD for UART, with RTS and CTS are configured as GPIO. Check in MCF52223 manual, if configuring CTS as GPIO causes disable CTS-to-TXD dependency (as in PowerQUICC family). If no, you will need to disable CTS-to-TXD dependency in the concerned UART register.