Hello SIVA VELUPPILLAI
According to your requirements, the VLPS is a good choice since the wake up from pin interrupt is available.
Just to clarify, what do you mean for "The LPO can do 250ms"? It's important to consider the transition time between the power modes, for the case of VLPS to Run the time is 2-4us + 12 clock cycles.
The LPO can be used with the watchdog and its available in VLPS.
Unfortunately, the LPO can't be calibrated, I apologize for the inconvenience this may cause you.
Let me know if this is helpful, if you have more questions do not hesitate to ask me.
Best regards,
Omar