Hi Mark,
There should be no jumpers you need to change. Is this an older TWR-LCD-RGB board you previously had, or did it come as part of the Vybrid kit (TWR-VF65GS10-PRO)? There were some older TWR-LCD-RGB that had some slightly tweaked firmware in the CRTouch module that could be causing this problem.Vybrid uses I2C to talk to the CRTouch located on the TWR-LCD-RGB board, and the CRTouch is what actually does the touch sensing on the screen.
Along with the Vybrid board version, what rev of TWR-LCD-RGB do you have? It's not the easy-to-read sticker on the TWR-ELEV board it's attached to. Instead you have to kind of tilt it, and read it at an angle from the right side edge on the back of the board where there should be 3 stickers lined up on top of each other:
One ending in something like "Rev E1" <--this is the rev version
One being a barcode
One ending in something like "Rev A"
-Anthony