Just to clarify, you would like the MCF52221 to act in device mode, correct? I think you can make it act as multiple devices by setting up separate endpoints. This would emulate a keyboard/mouse if you connected to a PC host.
On the other hand if you want to connect both a usb mouse and usb keyboard to a single MCF52221 and have it act in host mode, then this is more tricky. I'm not exactly sure of what it would require, but I believe you would need a usb switch or mux to select each one at a time. You'd also need the driver software for the devices.
Mac