Hello,
Yes, they are open-drain, pull-up resistors are REQUIRED on all upstream and downstream channels.
Yes, you should power the PCA954X switch with VDD=1.8V. The multiplexers/switches should be supplied with the lowest I2 C voltage needed to ensure proper voltage translation.
Please find more information here: https://www.nxp.com/docs/en/application-note/AN262.pdf
Hope this helps.
Hello,
Yes, you are right, please use the VDD within the limits.