Screenshot from the Reference Manual (K66P144M180SF5RMV2, Rev. 3, 04/2017, page 474):
If you are using I2C0 and I2C3 with DMA enabled, it could cause unpredictable behavior, because if a DMA request is triggered, you would not be able to know the true source of the DMA request (module 0 or 3). So, I wouldn't recommend enabling DMA support in both I2C modules.
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