Hello Jorgen,
Running the target MCU from a 3.3 volt supply, derived from pin 6 of the BDM header, may be a problem for 5 volt external peripherals during a debug session. However, since it appears that all 5 volt HCS08 devices are capable of operation at 3.3 volts, this should not present a problem for in-circuit programming.
On the schematic for the demo board, I notice that the circuit block representing the USB to BDM interface shows a Vcc_IN connection, to which Vdd is applied, from whichever source is used. I assume this is to allow for some variation of Vdd. The question still remains whether the voltage variation may extend to 5 volts.
To test this capability, the target Vdd should be applied to BDM header pin 6, and PWR_SEL jumper completely removed, as Peg has indicated. The Vx_EN jumper shouldn't matter since the connector J1 will not be used in this instance.
Regards,
Mac